利用变应原皮肤试验对比中西药抗组胺的作用-中医耳鼻咽喉科学专业论文.docx
4。小青龙汤对肺经风寒型变应性鼻炎患者有一定的疗效，可改善变应性鼻炎患者的临床症状，如鼻痒、喷嚏、鼻塞、流涕。
4。小青龙汤对肺经风寒型变应性鼻炎患者有一定的疗效，可改善变应性鼻炎患者
的临床症状，如鼻痒、喷嚏、鼻塞、流涕。
关键词：小青龙汤抗组胺药皮肤试验剂量一反应曲线下面积
Maki
Maki ng use of the Hi stami Re—ski n-test Compared the Function． of Ohi nese traditional medici Re and Western medi ci Re
SpeciaI ity：OtoIaryngoIogy Author：Lj Sun
Tutor：Ruan Yah
Abstract
Purpose：This research is a different and similar to make use of histamine—skin experiments to understand the Chinese herbal medicine antihistamine principle，contrast western medicine antihistamine function．
Methods：Draft 40 patients of AR that according with the standard．Establish small—blue—dragon soup group(20)，loratadine group(20)．Observe the object take the smali—blue—dragon soup，loratadine 10 mg．Histamine(20．1、7．3 mmol／L)and mite(1：100)skin tests were performed for each one before dosing and 7days after dosing．After 15 minutes measure wheal and flare areas， draw the AUDRC(area under dose—response curve，AUDRC)，using trapezoid method calculation AUDRC for each subject，recorded and compared the data． A11 data were analysis in multivaraiate ANOVA．
ResuIt：1．The wheal and flare area compared with itself after dose and before dose There was no significantly differed in smali—。blue—‘dragon soup(P>O．05)，in loratadine shows a highly significant treatment effecy(P<0．05)．
2．The wheal and flare area of small～blue—dragon soup compared with the loratadine group No significantly differde in，loratadine before dose(P>O．05)，no significantly differed in smali—blue—dragon soup，the analysis of the loratadine and small——blue——dragon soup shows a highly
significant treatment effect．(P<0．01)
3．AUDRC The dose—response curves Was no significantl differed in smal卜blue—dragon soup，ioratadine before dose(P>0．05)．The AUDRC of loratadine compared with with small——blue——dragon soup shows signifi—— cant．(P<0．05)
4．Both the curative projects have distinctly curative effect．Compared with the sympotoms before and after treatment，there is statistics distinguish (p<0．05)．T