最新流行病学文献评价报告

　　1、幻灯片1临床流行病学幻灯片2学生姓名:班级：学号：本（专）科专业：临床医学现攻读专业：老年医学导师：幻灯片3幻灯片4评价论文题目： Associati on betwee n low-dose folic acid suppleme ntati on and blood lipids concen trati ons in male and female subjects with atherosclerosis risk factors.出处： Med Sci Mon it. 2013; 19: 733刁39.设计类型：DRUG CONTROLLED STUDIES药物对照研究论文性质：预防

　　2、幻灯片5幻灯片6The aim of this study was to an alyze the associati on of low-dose folic acidsuppleme ntati on with blood lipids concen trati ons in subjects with atherosclerosis risk factors.Material/MethodsThe study en rolled 124 Caucasian in dividuals (60 M, ages 20-39; and 64 F, ages19 -39) with atheros

　　3、clerosis risk factors (family history of premature ischemicstroke, arterial hyperte nsion, dyslipidemia, overweight and obesity, cigarettesmok ing, and low level of physical activity). The participa nts were asked to takeFA at a low dose of 0.4 mg/24 h for 12 weeks.ResultsFA levels in creased in fem

　　4、ales (6.3 vs. 12.5 n g/dL; p=0.001) and males (6.4 vs.11.4 n g/dL; p=0.001) and Hcy levels decreased (10.6 vs. 8.3呵ol/L; p=0.001and 11.5 vs. 9.3; p=0.001, respectively). A sig ni fica nt reducti on in meancon ce ntration of total cholesterol in females (203.4 vs. 193.1 mg/dL; p=0.001)and in males (2

　　5、09.5 vs. 201.9; p=0.002) was observed. The low-de nsitylipoprote in cholesterol (LDL-C) levels decreased in females and in males (107.4vs. 99.9 mg/dL; p=0.001 and 121.5 vs. 115.1; p=0.002, respectively). The apoAI concen trati ons in creased in smok ing wome n and in men with BMI25 kg/m2(p=0.032 and

　　6、 p=0.024, respectively).Con clusi onsLow-dose FA suppleme ntati on has a ben eficial effect on blood lipids through decreas ing concen trati ons of total cholesterol and LDL-C and in creas ing concen trati ons of apoAI.幻灯片7幻灯片8However, the preve ntive effect of FA on cardiovascular disease rema ins

　　7、un clear.Large-scale cli nical trials failed to show a ben efit from Hcy-loweri ng treatme nt in in dividuals with established cardiovascular disease or with history of myocardial in farctio n. However, those studies evaluated high-dose FA suppleme ntatio n as sec on dary preve nti on and were not i

　　8、n vestigati ng low-dose FA suppleme ntati on as primary preve nti on of cardiovascular disease .文章的提出有科学性，有创新性，可行性，与临床密切相关 幻灯片9类型：药物对照(自身前后对照)，临床试验性研究样本选择：In itially, FA suppleme ntati on was offered to 147 subjects, 23 of whom (15.6%) were excluded in the course of the study due to non-complia nee

　　9、(irregular tak ing of FA, stopp ing it altogether, or not report ing for the follow-up exam in ati on at the end of the treatme nt period).未做样本含量估算。幻灯片10The study was approved by the Bioethics Committee of the Pomera nian Medical Un iversity in Szczeci n, Pola nd and a writte n consent was obta ined

　　10、 from all participa nts.经伦理委员会同意，患者知情同意，未使用盲法幻灯片11The study en rolled 124 Caucasian in dividuals (60 M, ages 20-39; and 64 F, ages19 -39) with atherosclerosis risk factors (family history of premature ischemic stroke, arterial hyperte nsion, dyslipidemia, overweight and obesity, cigarette smok ing,

　　11、and low level of physical activity).样本选取合适幻灯片12所用名词定义明确，诊断指标，测量方法，结局指标清晰，可靠性高幻灯片13共5个表，结果清晰，资料详尽，内部符合性高幻灯片14采用统计方法合理，按男女分层分析，再按不同危险因素分析，控制和调整了混杂因素幻灯片15In view of our results, it seems that low-dose FA suppleme ntati on, used asprimary preve ntio n, has a ben eficial effect on blood lipids through decreas ingconcen trati ons of total cholesterol and LDL and in creas ing concen trati ons of apoAI. To determ ine the value of FA in primary cardiovascular disease preve ntio n, further studies are needed.为研究所证实